Pauses, disfluencies and language problems in Alzheimer’s disease can be naturally modeled by fine-tuning Transformer-based pre-trained language models such as BERT and ERNIE.Using this method with pause-encoded transcripts, we achieved 89.6% accuracy on the test set of the ADReSS (Alzheimer’s Dementia Recognition through Spontaneous Speech) Ch
Abstract Background Dysregulated DNA repair and cell proliferation Diet controls are essential driving forces in mammary tumorigenesis.BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics.The aims of this study were to
Although the DEAD-box RNA helicase family is ubiquitous in eukaryotes, its developmental role remains unelucidated.Here, we report that cooperative action between the Arabidopsis nucleolar protein RH10, an ortholog of human DEAD-box RNA helicase DDX47, and the epigenetic repressor complex of ASYMMETRIC-LEAVES1 (AS1) and AS2 (AS1-AS2) is critical to
Misfolded proteins of the endoplasmic reticulum (ER) are eliminated by the ER-associated degradation (ERAD) in eukaryotes.In S.cerevisiae, ER-resident lectins mediate substrate recognition through bipartite signals consisting of an unfolded local structure and the adjacent glycan.Trimming of the glycan is essential for the directional delivery of t
Abstract Background Whilst there are comprehensive guidelines for the rehabilitation of people K Boots with severe impairments from stroke, there has been less attention on the health and rehabilitation needs of people with minor stroke.Our study will assess whether a new multi-component service pathway using an integrated model based around primar